选择语言:体中文|E‍nglish

 
招贤纳士


本课题组招收具有以下研究背景的博士后:

1. 细胞生物学

2. 分子生物学

3. 转基因鼠相关研究

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联系人:骞老师

电 话029-88461840

邮 箱:

qianair@nwpu.edu.cn

通讯地址陕西省西安市友谊西路127号,710072

研究成果

一、论文(*: 通讯作者):

  1. Peihong Su, Ye Tian, Chaofei Yang, Xiaoli Ma, Xue Wang, Jiawei Pei, and Airong Qian*.   Mesenchmal Stem Cell Migration during Bone Formation and Bone Diseases Therapy.Int. J. Mol. Sci.2018, 19(8), 2343; https://doi.org/10.3390/ijms19082343

  2. Yong-Guang Gao, Xiao Lin , Kai Dang, Shan-Feng Jiang, Ye Tian, Fen-Li Liu, Di-Jie Li, Yu Li, Zhi-Ping Miao and Ai-Rong Qian. Structure-activity relationship of novel low generation dendrimers for gene delivery. Organic & Biomolecular Chemistry, 2018, DOI: 10.1039/C8OB01767K

  3. Yong-Guang Gao, Uzair Alam, Ai-Xiang Ding, Quan Tang, Zheng-Li Tan, You-Di Shi, Zhong-Lin Lu, Ai-Rong Qian, [12]aneN3-based lipid with naphthalimide moiety for enhanced gene transfection efficiency. Bioorganic Chemistry, 2018, 79, 334-340.

  4. Hu L, Yin C, Zhao F, Ali A, Ma J, Qian A*. Mesenchymal StemCells: Cell Fate Decision to Osteoblast or Adipocyte and Application in Osteoporosis Treatment. Int J Mol Sci. 2018 Jan 25;19(2)

  5. Li S, Miao Z, Tian Y, Wang H, Wang S, He T, Yang Y, Wang P,Ma M, Yang T, Qian A* and Chen C*. Limethason reduces airway inflammation in a murine model ofovalbumin-induced chronic asthma without causing side effects. Experimental and Therapeutic Medicine. January 4, 2018

  6. Zhang Y, Yin C, Hu L, Chen Z, Zhao F, Li D, Ma J, Ma X, Su P,Qiu W, Yang C, Wang P, Li S, Zhang G, Wang L, Qian A*, Xian C. MACF1Overexpression by Transfecting the 21-kbp Large Plasmid PEGFP-C1A-ACF7 PromotesOsteoblast Differentiation and Bone Formation. Hum Gene Ther. 2018 Jan 15.

  7. Yin C1,2,3, Zhang Y1,2,3, Hu L1,2,3, Tian Y1,2,3, Chen Z1,2,3, Li D1,2,3, Zhao F1,2,3, Su P1,2,3, MaX1,2, Zhang G2,3, Miao Z1,2,3, Wang L4, Qian A1,2,3, Xian CJ4. Mechanical unloading reducesmicrotubule actin crosslinking factor 1 expression to inhibit beta-cateninsignaling and osteoblast proliferation. J Cell Physiol. 2017 Dec 8.

  8. Qian A1,Hu L2. Spectraplakins, versatile roles in physiologyand pathology. Semin Cell Dev Biol. 2017 Sep; 69:1-2.

  9. Miao Z, Ali A, Hu L, Zhao F, Yin C, Chen C, Yang T, Qian A*. Microtubule actin cross-linking factor 1, a novel potential target in cancer. Cancer Sci. 2017 Oct;108(10):1953-8.

  10. Zhihao Chen, Yan Zhang, Chao Liang, Lei Chen, Ge Zhang* and Airong Qian*; Mechanosensitive miRNAs and Bone Formation. Int .J .Mol. Sci. 2017, 18(8), 1684.

  11. Ali A1, Hu L1, Zhao F1, Qiu W1, Wang P1, Ma X1, Zhang Y1, Chen L1, Qian A2.BPAG1, a distinctive role in skin and neurological diseases.Semin Cell Dev Biol. 2017 Jun 13.doi: 10.1016/j.semcdb.2017.06.005

  12. Hu L1,2,3, Su P1,2,3, Yin C1,2,3, Zhang Y1,2,3, Li R1,2,3, Yan K1,2,3, Chen Z1,2,3, Li D1,2,3, Zhang G2,3, Wang L4, Miao Z1,2,3, Qian A1,2,3, Xian CJ4.Microtubule actin crosslinking factor 1 promotes osteoblast differentiation by promoting β-catenin/TCF1/Runx2 signaling axis.J Cell Physiol. 2017 Jun 16. doi: 10.1002/jcp.26059.

  13. Hu L1, Xiao Y1, Xiong Z1, Zhao F1, Yin C1, Zhang Y1, Su P1, Li D1, Chen Z1, Ma X1, Zhang G2, Qian A3. MACF1,versatility in tissue-specific function and in human disease.Semin Cell Dev Biol. 2017 May 31. pii: S1084-9521(16)30321-4.  doi: 10.1016/j.semcdb.2017.05.017.

  14. MIAO Zhi-ping,QIU Wu-xia,MA Xiao-li,QIAN Ai-rong. Advances in Research on Effects of Space Microgravity on Bone Metabolism. Journal of Astronautics.DOI: 10.3873/j.issn.1000-1328.2017. 03.001

  15. Miao Zhiping,Yin Chong,Zhang Yan,Hu Li-fang,Li Dijie,Chen Zhihao,Qian Airong. Effects of Simulated Weightlessness with Random Positioning Machine on Microtubule Actin Crosslinking Factor 1 Expression and β-catenin Pathway in Osteoblast. Space Medicine & Medical Engineering. 2017,30(1): 7-11

  16. Hu L1, Su P1, Li R1, Yin C1, Zhang Y1, Shang P1, Yang T2, Qian A1.Isoforms, structures, and functions of versatile spectraplakin MACF1.BMB Rep. 2016 Jan;49(1):37-44.  doi: 10.5483/BMBRep.2016.49.1.185.

  17. Kun Yan,Yasir Arfat,Dijie Li,Fan Zhao,Zhihao Chen,Chong Yin,Yulong Sun,Lifang Hu,Tuanmin Yang* & Airong Qian*.Structure Prediction:New Insights into Decrypting Long Noncoding RNAs. Int.J.Mol.Sci.2016,17(1),132 .

  18. Zhihao Chena, Fan Zhaoa, Yiduo Qia, Lifang Hua, Dijie Lia, Chong Yina, Peihong Sua, Yan Zhanga,Jianhua Maa,b, Jing Qiana, Hongpo Zhoua, Yiwei Zoua, Airong Qiana*, Simulated microgravity alters the expression of cytoskeleton- and ATP binding-related genes in MLO-Y4 osteocytes.Acta Astronautica 129 (2016) 186–192.

  19. Li Dijie1,Chen Zhihao1,Liu Zonglin1,Lin Yu1,Ding Chong1,Zhao Fan1,Arfat Yasir1,Hu Lifang1,Li Yongzhi2* ,Shang Peng1* ,Qian Airong1*.Qiang Gu Kang Wei Prescription Increases Bone Mineral Density of Load-bearing Bone in Tail Suspended Rats.Space Medicine & Medical Engineering.2016, 29(1)

  20. Lifang Hu, Peihong Su, Runzhi Li, Kun Yan, Zhihao Chen, Peng Shang & Airong Qian*. Knockdown of microtubule actin crosslinking factor 1 inhibits cell proliferation in MC3T3-E1 osteoblastic cells. BMB Rep. 2015, 48(10):583-8.

  21. Yang Wang, ZhiHao Chen, Chun Yin, JianHua Ma, DiJie Li, Fan Zhao, YuLong Sun, LiFangHu, Peng Shang*, AiRong Qian*.GeneChip Expression Profiling Reveals the Alterations of Energy MetabolismRelated Genes in Osteocytes under Large Gradient High Magnetic Fields.PLoS One. 2015, 10 (1): e0116359.

  22. Yasir Arfat,WeiZhong Xiao, Munazza Ahmad, Fan Zhao, Di-Jie Li, Yu-Long Sun, Li-Fang Hu,ZhiHao Chen, Ge Zhang, Peng Shang, AiRong Qian*. Role of microRNAs in osteoblasts differentiation and bone disorders.Current Medicinal Chemistry. 2015, 22 (6):748-58.

  23. YuLong Sun, Xiao-Hu Chen, ZhiHao Chen, Xiao-Li Ma,DiJie Li, Peng Shang, AiRong Qian*.Neuropeptide FF attenuates RANKL-induced differentiation of RAW264.7 cells intoosteoclast-like cells. Archives of Oral Biology. 2015, 60,282-292.

  24. YuLong Sun, Zhi-Hao Chen, XiaoHu Chen, Chong Yin,DiJie Li, Xiao-Li Ma, Fan Zhao, Ge Zhang, Peng Shang*, AiRong Qian*. Diamagnetic levitation promotes osteoclast differentiation from RAW264.7 cells. IEEE Transactions on Biomedical Engineering.2015, 62(3): 900-8.

  25. Chao Liang, Baosheng Guo,Heng Wu, NingSheng Shao, DeFang Li, Jin Liu, Lei Dang, Cheng Wang, Hui Li,Shao-Hua Li, Wing Ki Lau, Yu Cao, ZhiJun Yang, Cheng Lu, XiaoJuan He, D W TAu, XiaoHua Pan, BaoTing Zhang, ChangWei Lu, HongQi Zhang, KinMan Yue, AiRong Qian, Peng Shang, JiaKe Xu,LianBo Xiao, ZhaoXiang Bian, WeiHong Tan, ZiCai Liang, FuChu He,LingQiang Zhang*, AiPing Lu* & Ge Zhang*. Aptamer-functionalized lipidnanoparticles targeting osteoblasts as a novel RNA interference-based boneanabolic strategy. Nature Medicine. 2015, 21(3): 288-94.

  26. Jin Liu, LeiDang, DeFang Li, Chao Liang, XiaoJuan He, Heng Wu, AiRong Qian, ZhiJun Yang, Au, Doris W.T. Chiang, Michael W.L.,BaoTing Zhang, QuanBin Han, Yue, Kevin K.M. ; HongQi Zhang, ChangWei Lv,XiaoHua Pan, JiaKe Xu, ZhaoXiang Bian, Peng Shang, WeiHong Tan, ZiCai Liang, BaoSheng Guo, AiPing Lu, Ge Zhang. A delivery system specifically approaching bone resorption surfaces to facilitate therapeutic modulation ofmicroRNAs in osteoclasts. Biomaterials. 2015, 52:148-160.

  27. Yasir Arfat, Nasir Mahmood, Muhammad Usman Tahir,Maryam Rashid,Sameer Anjum, Fan Zhao, DiJie Li, YuLong Sun, Li-fang Hu,Zhihao Chen, Chong Yin, Peng Shang, AiRongQian*. Effect of imidacloprid on hepatotoxicity and nephrotoxicityin malealbino mice. Toxicology Reports, 2014, 1:554–561

  28. Yasir Arfat*, Nasir Mahmood, Munazza Ahmad, Muhammad Tayyab, Fan Zhao, DiJie Li, ZhiHao Chen, Chong Yin, Peng Shang, AiRong Qian. Effect of date palmpollen on serum testosterone and intra-testicular environment in male albinorats. Journal of Pharmacy and Pharmacology, 2014, 8(31):793-800.

  29. Yasir Arfat,WeiZhong Xiao, Salman Iftikhar, Fan Zhao, DiJie Li, YuLong Sun, Ge Zhang,Peng Shang, AiRong Qian*.Physiological effects of microgravity on bone cells. Calcified Tissue Internationaland Musculoskeletal Research. 2014, 94: 569-579

  30. YuLong Sun,Zhi-Hao Chen, XiaoLi Ma, DiJie Li, Fan Zhao, Peng Shang, TuanMing Yang*, AiRong Qian*. NeuropeptideFF inhibits LPS-mediated osteoclast differentiation of RAW264.7 cells. Protein& Peptide Letters. 2014, 22 (3):270-84.

  31. LiFang Hu, RunZhi Li,PeiHong Su, Peng Shang, AiRong Qian*. Response and Adaptation of Bone Cells to Simulated Microgravity. Acta Astronautica.2014, 104 (1): 396-408.

  32. Fan Zhao, DiJie Li, Yasir Arfat, Zhihao Chen ,Zong-Lin Liu, Yu Lin, Chong Ding, YuLong Sun, LiFang Hu, Peng Shang. AiRong Qian*. Reloading partly recovers bone mineral density and mechanical properties in hind limb unloadedrats. Acta Astronautica. 2014,105 (1): 57-65.

  33. AiRong Qian, Xiang Gao, Wei Zhang, JingBao Li, Yang Wang,ShengMeng Di, LiFang Hu, Peng Shang* Large Gradient High Magnetic Fields Affect Osteoblast Ultrastructure and Function by Disrupting Collagen I orFibronectin / αβ1 Integrin.PLoS One. 2013, 8 (1): e51036.

  34. Ai-Rong Qian; DaChuan Yin, Peng-Fei Yang, Yi Lv, ZongChengTian, Peng Shang*. Application of diamagnetic levitation technology inbiological sciences research. IEEE Transactions on AppliedSuperconductivity, 2013, 23 (1): 3600305.

  35. AiRong Qian, Lei Wang, Xiang Gao, Wei Zhang, LiFang Hu, JingHan, JingBao Li, ShengMeng Di, Peng Shang*.Diamagnetic levitation causes changes in the morphology, cytoskeleton and focal adhesion proteins in osteocytes. IEEE Transactions on Biomedical Engineering. 2012, 59 (1): 68-77.

  36. AiRong Qian, DongLi, Jing Han, Xiang Gao, ShengMeng Di, Wei Zhang, LiFang Hu, Peng Shang*.Fractal dimension as a measure of altered actin cytoskeleton in MC3T3-E1 cells under simulated microgravity using 3-D/2-D clinostats. IEEE Transactions on Biomedical Engineering. 2012, 59 (5): 1374- 1380.

  37. AiRong Qian, J.-P. Jin*.H2-Calponin Dynamics and Function in Cytokinesis.Biophysical Journal.2012, 102 (3): 373a.

  38. AiRong Qian, PengFei Yang, LiFang Hu, Wei Zhang, ShengMeng Di, Zhe Wang, Xiang Gao,Li Xie, YinYin Weng, JianPin Cao, Peng Shang*. High magnetic gradient environment causes alterations of cytoskeleton and cytoskeleton associated genes in human osteoblasts cultured in vitro. Advances in Space Research, 2010,46: 687-700.

  39. ZongLin Liu, AiRongQian*, Peng Shang. MACF1 and cytoskeleton. Chinese Journal of Cellular andMolecular. 2012,28 (2): 209-211.

  40. Yu Lin, AiRong Qian*, ZongLin Liu, PengShang. A mice hindlimb unloading (HLU) model to simulate microgravity. SpaceMedicine & Medical Engineering. 2012, 25 (4): 239-242.

  41. Wang Yang, AiRong Qian*, Peng Shang. The roles of stanniocalcin in bone metabolism in mammal.Chinese Journal of Cell Biology. 2014(4):343-348.

  42. AiRong Qian, PengFei Yang, LiFang Hu, Wei Zhang, ShengMeng Di, Zhe Wang, Xiang Gao, Li Xie, YinYin Weng, JianPin Cao, Peng Shang*. High magnetic gradient environment causes alterations of cytoskeleton and cytoskeleton associated genes in human osteoblasts cultured in vitro.Advances in Space Research, 2010, 46: 687-700.

二、 出版书籍:

  1. AirongQian. Antibody Fusion Protein , see Beifen Shen,Zhinan Chen, Minpei Liu ,Ed in Chief, Recombinant Antibodies, 2005,Scientific Press.

三、 专利:

  1. 叶芳,谢晋,何美莹,骞爱荣,常洪龙,一种基于单细胞捕获实现细胞定位培养芯片及其使用及制备方法。CN-106047706-B

  2. 骞爱荣,胡丽芳,王牌,马小莉,赵帆,仇伍霞,张茹,陈蕾,印崇,李迪杰,苏佩红,陈志浩,张琰,杨超飞,李思宇。MACF1定点转基因小鼠模型构建方法。201710672223.6

  3. 骞爱荣,胡丽芳,仇伍霞,马小莉,赵帆,张茹,王牌,陈蕾,印崇,陈志浩,苏佩红,李迪杰,张琰,李思宇,杨超飞。MACF1基因在成骨细胞中条件性敲除的小鼠模型的构建及应用。201710280283.3

  4. 骞爱荣,印崇,苗治平,张琰,胡丽芳,陈志浩,赵帆,李迪杰,马剑华,苏佩红,马小莉,仇伍霞,杨超飞,李思宇,王牌。长链非编码RNA Lnc-DIF的应用。201710036464.1

  5. 骞爱荣,胡丽芳,马剑华,李思宇,赵帆,陈志浩,李迪杰,陈楚,杨团民,印崇,苏佩红,马小莉,张琰,仇伍霞,张茹,王牌,杨超飞。老年骨质疏松性骨折的血清microRNA诊断标记物及其诊断试剂盒。CN106591487A

  6. 骞爱荣,马小莉,胡丽芳,赵帆,张茹,仇伍霞,王牌,苏佩红,陈志浩,李迪杰,印崇,苗治平,陈蕾。间充质干细胞中MACF1基因条件性敲除小鼠模型的建立及其应用。201710008830.2

  7. 骞爱荣,马剑华,赵帆,陈志浩,胡丽芳,李迪杰,印崇,马小莉,苏佩红。与老年性骨质疏松相关微小RNA的寡核苷酸化合物的应用。106167824A

  8. 骞爱荣,胡丽芳,印崇,赵帆,陈志浩,张琰,马剑华,苏佩红,李迪杰,仇伍霞,马小莉,王牌。MACF1基因及其表达产物在制备诊断和治疗骨质疏松症药物中的应用。106148520A

  9. 骞爱荣,胡丽芳,印崇,张琰,马剑华,赵帆,陈志浩,李迪杰,李思宇,马小莉,仇伍霞,杨超飞,王牌,苏佩红。miR-489-3p在制备诊断和治疗人骨质疏松症药物中的应用。CN106011264A;

  10. 骞爱荣,陈志浩,Yasir Arfat,印崇,胡丽芳,赵帆,李迪杰,张琰,李润芝,苏佩红,马小莉,仇伍霞。力学敏感的miR-138-5p作为药物靶点在骨骼肌肉系统疾病中应用。专利号:CN105169411A

  11. 骞爱荣,商澎,胡丽芳,李润芝,苏佩红,印崇,闫琨,陈志浩,戚依朵,孙瑜隆。抑制小鼠MACF1基因表达的shRNA序列及其应用。专利号CN104531700A

  12. 陈志南,黄宝成,商澎,骞爱荣,朱平。HAb18G(/CD147)肽类拮抗剂及其制备方法和用途。专利号ZL01131735.3

  13. 商澎,尹大川,骞爱荣,施朝华,薛小平,傅增祥,贾斌,田宗成,郑旭初,张维。大梯度强磁场中进行空间重力生物学模拟实验的装置。专利号:101188069;

  14. 商澎,李京宝,何刚,王亮,骞爱荣。利用戊二醛诱发红外荧光测定溶液蛋白质浓度的方法。专利号CN101846625A

  15. 李京宝,商澎,李亚楠,骞爱荣。过滤染色计数细胞的方法及装置。专利号:ZL 201120119330.4

  16. 李京宝,商澎,王蒙,王佳,李亚楠,骞爱荣。一种利用细胞脱壁试剂评测细胞脱壁强度的方法。专利号ZL201210199358.2

四、会议:

  1. Airong Qian*, Zhihao Chen, Yasir Arfat, Lifang Hu, Peng Shang, Ge Zhang. Mechanical unloading sensitive miR-138 targets MACF1 to regulate bone formation. 2015 American Society for Bone and Mineral Research (ASBMR), Seattle, USA, 2015, Oct. 9-12.

  2. Airong Qian*, Lifang Hu, Yulong Sun, Zhihao Chen, Yasir Arfat, Dijie Li, Chong Yin, Peihong Su, Runzhi Li, Kun Yan, Peng Shang, Ge Zhang. The Response of MACF1 to Simulated Microgravity and Its Noncoding RNAs in Regulating Osteogenesis. 6th China-Germany Workshop on Microgravity and Space Life Sciences Hangzhou, China. 2015.Sept.25-28

  3. Airong Qian*, Lifang Hu, Yulong Sun, Zhihao Chen, Yasir Arfat, Dijie Li, Chong Yin, Peihong Su, Runzhi Li, Kun Yan, Peng Shang, Ge Zhang. The role of MACF1 and its noncoding RNA in osteogenesis. The International Chinese Musculoskeletal Research Society (ICMRS) Conference and Xiangya Osteoporosis Forum, Changsha, China. 2015, April 9-11.

  4. AiRong Qian*, Li-Fang Hu, YuLong Sun, DiJie Li, Zhi-Hao Chen, Peng Shang, Ge Zhang. The role of MACF1 inmigration, proliferation and differentiation of Osteoblast and the screening ofthe natural antisense transcripts of MACF1. 2014 American Society for Boneand Mineral Research (ASBMR), Houston, USA. 2014, Sept. 12-15. (ISTP)

  5. AiRong Qian*, LiFang Hu, Yang Wang, Peng Shang. Response and Adaption of Bone Cells to Mechanical Stimulation. 2013 American Society for Bone and Mineral Research (ASBMR),Boltimore, USA. 2013, Oct. 4-7. (ISTP)

  6. AiRong Qian*, Xiang Gao, Wei Zhang, Lifang Hu, Peng Shang, JianPing Jin. Diamagneic levitation changes morphology,cytoskeleton architecture and h2-calponin expression in bone cells. BiophysicalSociety 55th Annual Meeting. Baltimore, Maryland,Mar5-9,2011.