Cheng-han Yu 博士学术报告会通知

报告题目：Spatial-temporal regulation of integrin activation, PI3K signaling, and podosome formation

报 告 人：Cheng-han Yu, Ph.D. HKU

主 持 人：骞爱荣 教授

报告时间：2016.9.27（周二）上午9:00—11:00

报告地点：生命学院一楼会议室

主办单位：西北工业大学生命学院

报告简介：

Extracellular signaling molecules can activate designated membrane receptors upon binding and trigger receptor oligomerization. Spatial-temporal clustering of membrane receptors serves as a reaction core for downstream biochemical reactions at the cellular interface. Integrin-mediated cell adhesion, a well-known example, involves micron-scale protein clustering and actin cytoskeleton remodeling at the interface of cell and extracellular matrices. I developed nano-patterned supported RGD membranes as a novel platform to decipher how mechanical cues in matrices regulate cell adhesion transformation. My recent report indicated that the formation of different adhesion structures, such as focal adhesion and podosome are modulated by mechanical characteristics of matrices. Lack of matrix-force at activated integrin clusters results in podosome formation in PI3K and FAK/PYK2 dependent manner. The switching between classic focal adhesions to macrophage-like podosomes is remarkable. While metastatic cancer cells also develop similar protrusive machinery, namely invadopodia, PI3K, FAK, and Pyk2 are all pharmaceutical targets to suppress tumor invasions. This groundbreaking finding directly suggests programmable adhesion transformation by matrix-mediated mechano-transduction.

报告人简介：

Cheng-han Yu (Ph.D. HKU)，graduated from National Taiwan University with a B.S. in Physics (2000). He then joined the research group of Jay T. Groves at University of California, Berkeley to complete his Ph.D. (2002-2007), focused on lipid membrane biophysics, T cell immunological synapse, and nanofabrication technology. Continuing his research interest in dynamical regulation of cellular membrane proteins, Dr. Yu started his postdoctoral training with Michael P. Sheetz at Mechanobiology Institute (MBI) in National University of Singapore. In August 2014, Dr. Yu joins the School of Biomedical Sciences in the University of Hong Kong.