Research

Mechanobiology:

From the molecular, cellular, tissue and whole animal level to conduct the mechanism study of mesenchymal stem cells and osteoblast differentiation, load-bearing bone formation and skeletal system related diseases under different mechanical conditions. Choose mechanics sensitive genes (MACF1) and non-coding RNA (microRNA, LncRNA) as breakthrough points to study the molecular mechanism of bone formation while mechanical loading alters.Our research team has established conditional knockout mouse models (fl/fl,Prrx1/+; fl/fl, sp7/+) disrupting MACF1 expression in pre-osteoblasts and mesenchymal stem cells, MACF1 knockin mice through ROSA26 locus and mir-138 transgenicmouse models.

Epigenetic Research on Bone Metabolism Disorders and Nucleic Acid Drug Development:

Focus on osteoporosis, osteoma, osteoarthritis and other bone related disease, evaluate the epigenetic changes of these diseases; screen nucleic acid or small molecule drugs. To be specific, MACF1 was taken as the star molecule, its natural antisense RNA (MACF1AS) was screened; and microRNA/lncRNA that associated with bone metabolism disorder were selected as well to uncover their involvement of bone metabolism diseases; further nucleic acid or small molecule drugs will be developed to prevent and treat metabolic bone diseases.

Human Machine and Environment Engineering:

We devote ourselves to “the impact of special physical environment (electromagnetic radiation, noise, vibration, ultrasound) on the health of special operations personnel”. According to the biological effects, the drugs for preventing and controlling the harm of special physical environment to human will be developed, and the protection for people will be achieved. Our research include: the effects of special physical environment on operators; biological effect assessment of special physical environment and protection policy draft; establish biological safety standards of various electromagnetic radiation physical environment.